MOTIV™ MSK Collaboration Launches Strongly
February 19, 2026
MOTIV™ MSK Collaboration Launches Strongly
MOTIV™ – the MSK real-world evidence collaboration between RegenMed and OREF – is off to a strong start.
The initial MOTIV™ Observational Protocol (OP) is based upon the mandated CMS TKA PRO PM, but also collects product, surgical technique, pain management, and other real-world data. The OREF expert-reviewed OP was co-authored by Doctors Andrew Wickline and John Mercuri. WCG Clinical Services has issued its Certificate of Action confirming that the generation of Circle Datasets pursuant to that OP is exempt under 45 CFR 46.104(d)(4).
Orthopedic surgeons from around the country, and representing over 2,000 TKAs annually, have already joined as Circle Members and begun enrolling Cases. Many more have indicated their intention to join.
Last week’s initial Circle Hour brought together current and interested Circle Members. Topics included positive feedback on clinician and patient experience, benefits of national collaboration on TKA topics of common interest, and the opportunities for publication and Circle Dataset licensing. RegenMed and OREF will be hosting another Circle Hour at the Academy meeting in New Orleans in early March.
The FDA TEMPO and CMS ACCESS programs are prioritizing fit-for-purpose, verifiable real-world evidence for several major therapeutic areas, including MSK. Circle Datasets not only meet these requirements, they do so with excellent physician UX, collaboration and ethical financial participation.
Please contact Alyssa Johncola or Erika Deleon to learn more.
MOTIV™ MSK Collaboration Launches Strongly
February 19, 2026
MOTIV™ – the MSK real-world evidence collaboration between RegenMed and OREF – is off to a strong start.
The initial MOTIV™ Observational Protocol (OP) is based upon the mandated CMS TKA PRO PM, but also collects product, surgical technique, pain management, and other real-world data. The OREF expert-reviewed OP was co-authored by Doctors Andrew Wickline and John Mercuri. WCG Clinical Services has issued its Certificate of Action confirming that the generation of Circle Datasets pursuant to that OP is exempt under 45 CFR 46.104(d)(4).
Orthopedic surgeons from around the country, and representing over 2,000 TKAs annually, have already joined as Circle Members and begun enrolling Cases. Many more have indicated their intention to join.
Last week’s initial Circle Hour brought together current and interested Circle Members. Topics included positive feedback on clinician and patient experience, benefits of national collaboration on TKA topics of common interest, and the opportunities for publication and Circle Dataset licensing. RegenMed and OREF will be hosting another Circle Hour at the Academy meeting in New Orleans in early March.
The FDA TEMPO and CMS ACCESS programs are prioritizing fit-for-purpose, verifiable real-world evidence for several major therapeutic areas, including MSK. Circle Datasets not only meet these requirements, they do so with excellent physician UX, collaboration and ethical financial participation.
Please contact Alyssa Johncola or Erika Deleon to learn more.
