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Canadian Peptide Research Society Newsletter

Client News
October 28, 2025
We’re thrilled to share exciting updates from the Canadian Peptide Research Society (CPRS) and its founder, Dr. Grant Pagdin, a pioneer in regenerative medicine and peptide therapy. Dr. Pagdin has long championed the responsible clinical use of peptides, and his leadership continues to shape ...
Dear Colleagues,We’re thrilled to share exciting updates from the Canadian Peptide Research Society (CPRS) and its founder, Dr. Grant Pagdin, a pioneer in regenerative medicine and peptide therapy. Dr. Pagdin has long championed the responsible clinical use of peptides, and his leadership continues to shape the future of integrative medicine in Canada and North America.Why Did Dr. Pagdin Start CPRS?The Canadian Peptide Research Society was founded to legitimize the science and clinical use of peptides across North America and Canada. With a growing body of evidence supporting peptide therapies, CPRS will serve as a central hub for clinicians, researchers, and educators to collaborate, share data, and advance safe, effective treatment protocols.Meet Our Board of DirectorsCPRS is guided by a distinguished Board of Directors, composed of leaders in peptide research, clinical practice, and biotechnology - each bringing unique expertise to the society:‍Dr. Grant Pagdin, MD, CCFP, FCFP, ABAARM: Principal of CPRS, with a focus on regenerative research and clinical innovation.‍Chris Kemppainen, B.Sc., B.Sc.(Pharm), RPh: Founder of Kiwi Pharmacy and Wellness, specializing in functional and natural medicines.‍Dr. Trevor Hoffman, ND: A pioneer in regenerative medicine, with expertise in orthopedic and cosmetic applications.Why Join CPRS?Joining CPRS means becoming part of a dynamic community dedicated to advancing peptide therapies responsibly and effectively. Our society stands for:Data Collection & Research: We’re pioneering efforts to gather real-world evidence on peptide treatments, crucial for establishing safety, efficacy, and clinical hypotheses.Safety & Efficacy: Our commitment to evidence-based practice ensures that peptide therapies are safe and effective for patients.Clinical Innovation: We support hypothesis-driven research into peptide applications for MSK conditions, gut health, skin rejuvenation, and more.Educational Opportunities: Attend conferences, participate in exclusive white papers, and stay abreast of the latest scientific developments.Partnerships & Data Initiatives: In collaboration with RegenMed, CPRS is launching data collection efforts through Physician-Owned Circles, focusing on innovative treatment areas.Upcoming ConferenceJoin Dr. Pagdin and CPRS representatives at the upcoming Age Management Medicine CME Conference in Salt Lake City, Utah, from November 12–16, 2025. This is a great chance to expand your knowledge of peptide therapies, connect with leading experts, and discuss potential collaborations.We look forward to connecting with you and advancing peptide science together.Warm regards,Dr. Grant Pagdin and the CPRS Team
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The Modern Imperative of Physician Communication: Opportunity, Responsibility, and the Circles Promotion Program

Article
October 7, 2025
Discover how physicians can confidently share their expertise online while navigating complex regulations. Learn about RegenMed’s Circles Physician Promotion Program — your pathway to credible, compliant, and impactful digital engagement.
IntroductionIn today’s digital age, physicians no longer operate solely within clinic walls. Their voices extend across social media, webinars, professional forums, and public platforms — shaping patient trust, influencing health behavior, and defining professional reputation. As digital engagement becomes central to healthcare’s future, physicians face both unprecedented opportunities and heightened risks. Effective public communication is now not only a professional differentiator but also a regulatory responsibility requiring adherence to evidence-based standards. To navigate this evolving landscape, physicians must adopt structured, compliant, and strategically guided communication programs. RegenMed’s Circles Physician Promotion Program is designed to empower clinicians with the tools, platforms, and safeguards needed to share their expertise confidently and credibly.The Strategic Value of Public CommunicationThe digital transformation of healthcare has democratized information, making expert medical voices more visible — and more necessary — than ever before. Accurate, relatable, and evidence-based messaging combats misinformation, fosters patient understanding, and strengthens population health initiatives. For physicians, public communication also creates: Professional differentiation, highlighting data-driven outcomes and thought leadership.Patient engagement, by translating complex insights into accessible narratives.Peer recognition, through collaboration on shared observational protocols and dissemination of findings.Career advancement, as health systems increasingly value digital credibility and outreach capabilities. Yet, the same visibility that builds reputation also invites scrutiny. Physicians must balance influence with integrity, ensuring every public statement aligns with the ethical rigor expected in clinical practice.Regulatory and Ethical ConsiderationsPublic communication is not exempt from professional standards. According to the American Medical Association (AMA) and Federation of State Medical Boards (FSMB), physicians carry identical ethical responsibilities in digital spaces as in direct patient care. Key regulatory domains include:Federal Trade Commission (FTC) oversight of advertising and promotional claims, requiring Competent and Reliable Scientific Evidence (CRSE) to substantiate any statements about treatment efficacy.State Medical Board jurisdiction, addressing misinformation and “unprofessional conduct,” which can trigger licensure investigations or sanctions.HIPAA/HITECH compliance, demanding strict de-identification of any shared clinical data, whether by Safe Harbor (removal of 18 identifiers) or Expert Determination (statistical certification).Professional liability exposure, including malpractice and informed consent claims arising from inaccurate or exaggerated public claims.Conflict of interest transparency, to ensure independence and avoid perceptions of self-dealing. In this environment, structured governance is essential. Communications must be accurate, documented, de-identified, and fully transparent about financial or professional interests.Best Practices for Responsible Physician CommunicationTo safeguard both physicians and their institutions, communications should reflect five essential principles: Evidence-Based Claims: All public statements must be anchored in verified clinical data and peer-reviewed outcomes. Privacy Protection: No identifiable patient information should ever be disclosed without explicit consent and proper de-identification. Professional Boundaries: Maintain separation between personal and professional social media; avoid forming unintended patient relationships online.Transparency: Clearly disclose any financial relationships or research affiliations relevant to the content shared. Documentation: Retain records of all communications involving clinical claims or patient data in secure, auditable systems. These standards elevate public communication from marketing to a form of evidence-based public health education — reinforcing both trust and compliance.The Circles Physician Promotion Program: A Compliant Pathway to InfluenceRegenMed’s Circles platform already enables participating physicians to collect high-quality, longitudinal real-world evidence (RWE). The Circles Physician Promotion Program extends that value by transforming validated data into credible, impactful communication assets — all at no additional cost.Program ComponentsCircle Hours: Moderated, secure Zoom sessions presenting clinical hypotheses, real-world outcomes, and best practices — with full video editing and highlight vignettes for reuse.Website and Newsletter Content: Professionally produced short-form videos and articles showcasing data insights, thought-leader collaborations, and upcoming conference activities.Social Media Campaigns: Evidence-based posts aligned with regulatory guidance, promoting physician expertise while preserving compliance.Conference Support: Assistance with slide decks, brochures, and post-event communications for Circle investigators and co-investigators.Co-Investigator Recruitment: Guidance and outreach to bring aligned clinicians into similar observational protocols, strengthening professional networks. Each element is built on RegenMed’s rigorous compliance framework, ensuring that physician communications remain factually grounded, legally sound, and professionally advantageous.ConclusionIn the modern healthcare ecosystem, communication is clinical practice. Physicians who articulate their expertise — responsibly, transparently, and evidence-first — amplify their impact beyond the exam room. Yet, the legal and ethical complexities of public engagement demand structured, expert support. The Circles Physician Promotion Program bridges this gap. By merging real-world data, compliant messaging, and professional-grade media, it transforms physician communications into strategic assets — enhancing clinical reputation, supporting patient education, and driving professional growth, all while safeguarding regulatory compliance. It is your data — and with the right platform, it can serve your clinical, professional, and financial interests responsibly.‍
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From Empirical Pain Relief to Predictive Precision: How RegenMed Circles Enable Clinically and Statistically Significant PNS Protocols

Article
October 2, 2025
Peripheral Nerve Stimulation (PNS) is transforming the landscape of pain management. Once seen as a last resort for intractable neuropathic pain, it now stands at the forefront of non-opioid, precision-based interventions. Yet, despite its promise, PNS has long been held back by one fundamental gap
How RegenMed Circles Enable Clinically and Statistically Significant PNS ProtocolsPeripheral Nerve Stimulation (PNS) is transforming the landscape of pain management. Once seen as a last resort for intractable neuropathic pain, it now stands at the forefront of non-opioid, precision-based interventions. Yet, despite its promise, PNS has long been held back by one fundamental gap: the inability to reliably predict which patients will benefit, and under which stimulation parameters. Clinical success has often relied on trial-and-error rather than science. RegenMed Circles changes that paradigm.Closing the Evidence Gap with Circles RegenMed Circles is a real-world evidence (RWE) platform designed to bring scientific rigor and statistical power to PNS therapy. By standardizing observational protocols, integrating validated Patient-Reported Outcome Measures (PROMs), and aligning with payer-recognized ICD-10 indications, Circles enables a new generation of PNS research — one that is clinically meaningful, reproducible, and regulatory-grade.Circles moves beyond empirical feedback to structured, data-driven insights. It systematically collects pain intensity, functional outcomes, psychological metrics, and opioid utilization data across diverse populations, allowing clinicians and manufacturers to identify what truly drives long-term success.Implementing Clinically and Statistically Significant PNS ProtocolsOur recently published White paper proposes three important Observational Protocols (OPs) for PNS therapy — each designed to address high-impact clinical challenges and generate evidence suitable for coverage expansion:Post-Amputation Pain: Validates early PNS intervention as a prophylactic, opioid-sparing therapy to prevent phantom limb pain.Genicular Nerve Stimulation: Measures pain relief and functional restoration in chronic knee pain, linking PROMs such as WOMAC and KOS-ADL to payer-relevant outcomes.Postherpetic Neuralgia**: Evaluates durable efficacy of permanent PNS implants in severe neuropathic pain, with a focus on quality of life and sleep interference metrics.Each OP leverages Circles’ architecture to achieve clinically and statistically significant results. By standardizing inputs and outputs across multi-center sites, Circles delivers the statistical power necessary to draw credible conclusions — transforming individual case studies into population-level insight.From Empirical Practice to Predictive PrecisionThe future of PNS lies not just in better devices, but in better data. Circles integrates anatomical, psychological, and outcome data to inform predictive models for stimulation optimization. This shift from reactive to predictive programming aligns PNS therapy with modern precision medicine standards.By embedding computational modeling, validated PROMs, and longitudinal tracking, Circles enables clinicians to personalize therapy while giving payers and regulators the reproducible evidence they demand. The result: safer, more effective, and financially sustainable PNS care.A Platform for Clinical, Regulatory, and Market SuccessIn a market projected to more than double by 2033, RegenMed Circles positions stakeholders to lead. It provides manufacturers with evidence for FDA and CMS alignment, clinicians with actionable insights, and payers with proof of value. By uniting clinical outcomes with compliance integrity, Circles builds a foundation for scalable, non-opioid pain care.ConclusionRegenMed Circles turns the promise of PNS into predictive precision. By designing and executing clinically valid, statistically robust observational protocols, it bridges the gap between innovation and validation — unlocking the full therapeutic and commercial potential of peripheral nerve stimulation.
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